Trust has been identified as an indicator within Social Quality theory. As an important component of social quality, trust has become increasingly important in modern society because literature suggests that trust in a number of democratic countries is declining. Modern technologies and specialties are often beyond the understanding of lay individuals and thus, the need for trusting relations between lay individuals and organizations/individuals has grown. The purpose of the study was to examine the extent to which Australians (dis)trust individuals and (...) organizations/institutions. A national postal survey was conducted with 1,044 respondents recruited using the electronic white pages directory. Findings from multivariate analyses suggest that income, age, sex, and health status are associated with trust in groups of individuals and trust in organizations/institutions. The findings highlight populations where trust needs to be (re)built. Future government policy and practice should utilize these findings as a means of facilitating social quality. (shrink)

This collection of original essays explores the connections between the philosophies of Alfred North Whitehead and the classical American pragmatists.

In this expensive but invaluable book, students and scholars of Whitehead's philosophy and those more generally interested in the intersections of philosophy and science will find a treasure trove for gleaning the development, breadth, and depth of Whitehead's thought. This work, which consists of three independent sets of course notes from the previously unpublished lectures that Whitehead gave in his first year at Harvard in 1924–1925, is the first volume in a new and richly important series by Edinburgh University Press: (...) The Edinburgh Critical Edition of the Complete Works of Alfred North Whitehead, overseen by series editors George R. Lucas Jr. and Brian G. Henning. This initial volume, which was skillfully... (shrink)

This is the first full English translation of Bernard Bolzano's masterwork, the Theory of Science (1837)--a monumental and revolutionary study in logic, epistemology, heuristics, and scientific methodology. Each volume includes an introduction which illuminates the historical context of Bolzano's work and its continuing relevance.

Politically motivated attacks against civilians are typically evaluated by focusing on objective factors, such as the loss of innocent life, the justness of a rebel organization's political vision, and whether the attacks are successful in advancing that vision. Albert Camus' philosophy on rebellion provides an alternative approach that focuses on subject experience of the rebel. The rebel experiences a genuine moral dilemma created by the passionate desire to fight injustice and the feeling of universal solidarity that encompasses even those who (...) the rebel believes it is necessary to kill. From this standpoint, any action the rebel takes is immoral. Camus thus makes authenticity the focus of his analysis. Authentic rebels continue to value solidarity, which creates a limit on how violence can be used in rebellion. Drawing from The Rebel and The Just Assassins, this paper develops several criteria for immoral but authentic acts of political violence, which are then applied to suicide bomb attacks directed against civilians. (shrink)

Recent Anglophone scholarship has successfully shown that Nietzsche's thought makes important contributions to a wide range of contemporary philosophical debates. In so doing, however, scholarship has lost sight of another important feature of Nietzsche's project, namely his desire to challenge the very conception of philosophy that has been used to assess his merits as a philosopher. In other words, contemporary scholarship has overlooked Nietzsche's contributions to metaphilosophy, i.e. debates around the nature, methods, and aims of philosophy. This important new collection (...) of essays brings together an international group of distinguished scholars to explore and discuss these contributions and debates. It will appeal to anyone interested in metaphilosophy, Nietzsche studies, German studies, or intellectual history. (shrink)

George A. Paul; Reports of Discussions at Cardiff (Joint Session of Mind Association and Aristotelian Society, July 1934)1, Analysis, Volume 2, Issue 1-2, 1 Oct.

A common view is that ceteris paribus clauses render lawlike statements vacuous, unless such clauses can be explicitly reformulated as antecedents of ?real? laws that face no counterinstances. But such reformulations are rare; and they are not, we argue, to be expected in general. So we defend an alternative sufficient condition for the non-vacuity of ceteris paribus laws: roughly, any counterinstance of the law must be independently explicable, in a sense we make explicit. Ceteris paribus laws will carry a plethora (...) of explanatory commitments; and claims that such commitments are satisfied will be as (dis) confirmable as other empirical claims. (shrink)

In attempting to provide protection to individuals and communities, childhood immunization has benefits that far outweigh disease risks. However, some parents decide not to immunize their children with some or all vaccines for reasons including lack of trust in governments, health professionals, and vaccine manufacturers. This article employs a theoretical analysis of trust and distrust to explore how twenty-seven parents with a history of vaccine rejection in two Australian cities view the expert systems central to vaccination policy and practice. Our (...) data show how perceptions of the profit motive generate distrust in the expert systems pertaining to vaccination. Our participants perceived that pharmaceutical companies had a pernicious influence over the systems driving vaccination: research, health professionals, and government. Accordingly, they saw vaccine recommendations in conflict with the interests of their child and “the system” underscored by malign intent, even if individual representatives of this system were not equally tainted. This perspective was common to parents who declined all vaccines and those who accepted some. We regard the differences between these parents—and indeed the differences between vaccine decliners and those whose Western medical epistemology informs reflexive trust—as arising from the internalization of countering views, which facilitates nuance. (shrink)

Activation of resting T lymphocytes through the T cell antigen receptor complex is initiated by critical phosphorylation and dephosphorylation events that regulate the function and interaction of a number of signaling molecules. Key elements in these reactions are members of the Src, Syk and Csk families of protein tyrosine kinases (PTKs) and the phosphotyrosine phosphatases (PTPases) that regulate and/or counteract them, such as CD45. The PTKs can autophosphorylate and phosphorylate each other at multiple sites and, as the result of these (...) interactions, they are induced to phosphorylate other cellular proteins. These phosphorylation events lead to modulation of enzymatic activities and/or serve as binding sites for other signaling molecules having phosphotyrosine‐binding Src homology 2 (SH2) domains. As a result, these proteins translocate to the receptor complexes and are juxtaposed to the kinases that phosphorylate them. Some of the SH2‐domain‐containing polypeptides lack enzymatic activities and, instead, serve as adapter molecules that couple the signal to downstream effectors, such as regulators of the Ras proteins, and further into serine/threonine‐specific protein kinase cascades. Through largely unknown steps these reactions lead to the transcription of previously silent genes, activation of lymphocyte effector functions, progression through the cell cycle and cell proliferation. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

Brain Computer Interface (BCI) technology offers potential for human augmentation in areas ranging from communication to home automation, leisure and gaming. This paper addresses ethical challenges associated with the wider scale deployment of BCI as an assistive technology by documenting issues associated with the development of non-invasive BCI technology. Laboratory testing is normally carried out with volunteers but further testing with subjects, who may be in vulnerable groups is often needed to improve system operation. BCI development is technically complex, sometimes (...) requiring lengthy recording sessions to achieve the necessary personalisation of the paradigms, and this can present ethical challenges that vary depending on the subject group. The paper contributes to the on-going ethical discussion surrounding the deployment BCI outside the specialist laboratory and suggests some tentative guidelines for BCI research teams, appropriate to those deploying the technology, derived from experience on a multisite project. Any tension between deployment and technical progress must be managed by a formal process within a multidisciplinary consortium. (shrink)

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. (...) SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk‐benefit profile. (shrink)

This volume comprises a selection of papers that were contributed to the 7th International Congress of Logic, Methodology and Philosophy of Science, which was held in Salzburg from the 11th - 16th July, 1983. There were 14 sections in this congress: 1. proof theory and foundations of mathematics 2. model theory and its applica ti on 3. recursion theory and theory of computation 4. axiomatic set theory 5. philosophical logic 6. general methodology of science 7. foundations of probability and induction (...) 8. foundations and philosophy of the physical sciences 9. foundati ons and phi 1 osophy of biology 10. foundations and philosophy of psychology foundations and philosophy 11. of the social sciences 12. foundati ons and philosophy of linguistics 13. history of logic, methodology and philosophy of science 14. fundamental principles of the ethics of science In each section, three or four invited addresses were given, which will be published in the Congress Proceedings (Ruth Barcan Marcus, Georg J. W. Dorn and Paul Weingartner, eds. : Logic, Metho dology and Philosophy of Science VII. Proceedings of the Seventh International Congress of Logic, Methodology and Philosophy of v PREFACE Science, Salzburg, 1983. - Amsterdam, New York, Oxford: North-Holland Publishing 'Company, 1985. ) Every section with the exception of section 14 also contained contributed papers. (shrink)

The organizational justice literature and the family business literature have developed independently, which limits our understanding of fairness and justice in the family business workplace. So far, the concepts of justice and fairness have been used interchangeably in the family business literature, as if objective measures that aim to increase justice in the workplace will automatically translate into fairness perceptions among family business employees. By integrating the organizational justice literature and the family business literature, we first differentiate between the two (...) concepts of justice and fairness and argue that a utilitarian conceptualization of justice may come into direct conflict with fairness perceptions in the family business workplace. Second, we shed light on the importance of incorporating socioemotional goals, particularly those that reveal a bright side of socioemotional wealth, into rules and regulations designed to increase justice in the workplace, which, we argue, contributes to increasing fairness perceptions among employees and to building and maintaining an ethical family business workplace. Theoretical and practical contributions are discussed at the end of the paper. (shrink)

We examine the relationship between Japanese foreign direct investment (FDI) and the national corporate responsibility (NCR) environment in host countries using corporate social responsibility and international business theories. Based on data from the Japanese Government’s Ministry of Finance AccountAbility, and other sources, we find that the level of NCR has a positive relationship with FDI inflow for developing countries. The relationship for developed countries is negative but not statistically significant. The underlying host country development stage moderates the relationship. The results (...) can help deepen understanding of FDI behaviors and have practical implications for host countries in terms of attracting FDI. (shrink)

Name der Zeitschrift: Jahrbuch für Wissenschaft und Ethik Jahrgang: 21 Heft: 1 Seiten: 197-220. -/- There seem to be good reasons that democratic institutions must be reformed in order to minimize the danger of unsustainable policy decisions infringing upon duties of intergenerational justice. This is why there exist a number of different proposals of how to reform democratic states in order to foster their duties towards the future. However, the debate lacks a systematic assessment of these suggested reforms within a (...) coherent theoretical and norma-tive framework. This paper aims at developing such a framework. We suggest two conceptual dimensions defining the spectrum of different justi-fiable institutional reforms: the relation between democracy and justice as one dimension and the conditions considered relevant for viewing democracies as responsible collective agents as the other. Depending on how we understand this relation and these conditions, it is possible to substantiate a set of types of institutional reforms that will promote democracies? capacities to comply with their responsibilities towards the future. (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick Ferré. These essays, informed by the insights of Ferré and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick FerrZ. These essays, informed by the insights of FerrZ and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

A leading authority in contemporary and digital photography places images of the transitions of American cities in the 1980s and 1990s beside Sartre's meditative essays based on an extended visit to America in 1945, in a volume originally published as part of The Aftermath of War.

We investigate notions of randomness in the space ${{\mathcal C}(2^{\mathbb N})}$ of continuous functions on ${2^{\mathbb N}}$ . A probability measure is given and a version of the Martin-Löf test for randomness is defined. Random ${\Delta^0_2}$ continuous functions exist, but no computable function can be random and no random function can map a computable real to a computable real. The image of a random continuous function is always a perfect set and hence uncountable. For any ${y \in 2^{\mathbb N}}$ , (...) there exists a random continuous function F with y in the image of F. Thus the image of a random continuous function need not be a random closed set. The set of zeroes of a random continuous function is always a random closed set. (shrink)

The molecular mechanism of temperature‐dependent sex determination (TSD) is a long‐standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D‐TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity to remodel (...) in response to temperature by changing 3D chromatin conformation, perhaps via temperature‐sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex‐determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex‐determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate. (shrink)